/* BioScope: white space, navy accents, original scientific illustration. */
:root{--ink:#17212b;--green:#1f4e79;--muted:#5c6773;--line:#dce3ea;--paper:#fff;--tint:#eef4f8;--navy:#0b1f3a}
body{background:#fff;color:var(--ink)}
a{transition:color .15s}a:hover{color:#1f4e79}a:focus-visible,button:focus-visible,input:focus-visible,select:focus-visible{outline:2px solid #1f4e79;outline-offset:4px}
.edition{border-top:3px solid var(--navy);font-size:10px;letter-spacing:1.1px;color:var(--muted)}.edition i{color:var(--muted)}
header{padding:27px 0;gap:36px}.brand{display:inline-flex;flex-direction:column;gap:5px;letter-spacing:0;line-height:1;color:var(--navy);font-weight:400}.brand .wordmark{font:42px/1 'Libre Caslon Display',Georgia,serif;letter-spacing:-1.4px;color:inherit}.brand .brand-sub{font:9px/1.4 'DM Sans',Arial,sans-serif;letter-spacing:3.6px;color:inherit;padding-left:2px}.edition-link{color:var(--green)}
nav{background:white;border-bottom:1px solid var(--navy)}nav a{font-size:13px;padding:18px 0;color:var(--navy)}nav a.active{color:var(--navy);box-shadow:inset 0 -2px var(--navy)}nav button{color:var(--muted)}
main{padding-top:32px}.kicker{padding-bottom:24px}.eyebrow{color:var(--green);font-size:10px;letter-spacing:1.3px}.eyebrow .dot{color:#5e7c99}.byline{font-size:11px;flex-wrap:wrap;line-height:1.7;gap:10px}.byline strong{font-weight:400}.all-link{font-size:12px;color:var(--green)}
.feature{display:grid;grid-template-columns:1.1fr 1fr;gap:46px;align-items:center;border-bottom:1px solid var(--line);padding-bottom:32px}.feature-image{display:block}.editorial-image{display:block;width:100%;height:auto;aspect-ratio:3/2;object-fit:cover;background:#f9fbfd}.feature-copy h1{font:52px/1.07 'Libre Caslon Display',Georgia,serif;letter-spacing:-.7px;color:var(--navy);margin:18px 0}.feature-copy .deck{font-size:16px;line-height:1.7;color:var(--muted);margin:0 0 22px}.feature-copy .all-link{display:inline-block;margin-top:12px}.brief-note{display:flex;justify-content:space-between;gap:25px;font-size:11px;color:var(--muted);padding:16px 0;margin-bottom:38px;border-bottom:1px solid var(--line)}.brief-note a{color:var(--green)}
.section-heading{border-bottom:1px solid var(--line);padding-bottom:16px}.section-title{font-size:31px;color:var(--navy)}.latest-grid{display:grid;grid-template-columns:1fr 1fr;gap:0 38px}.story-row{display:grid;grid-template-columns:190px minmax(0,1fr);gap:24px;padding:26px 0;align-items:start}.story-row h2{font-size:29px;line-height:1.13;margin:10px 0;color:var(--navy)}.story-row p{font-size:13px;line-height:1.7;margin:9px 0;color:var(--muted)}.story-image{display:block}.story-row .editorial-image{aspect-ratio:4/3}.story-row .date-line{margin:12px 0 0;font-size:10px;color:var(--muted);line-height:1.8}.latest-grid .story-row{grid-template-columns:150px minmax(0,1fr);gap:20px}.latest-grid .story-row h2{font-size:26px}.latest-grid .story-row .eyebrow{font-size:9px}
.signals{background:#fff;border-top:1px solid var(--navy);border-bottom:1px solid var(--line);padding:26px 0;gap:28px;margin:42px 0 48px}.signals h2{color:var(--navy)}.signals h3{position:relative;padding-left:14px;color:var(--navy);font-size:13px;line-height:1.6}.signals h3:before{content:'';position:absolute;left:0;top:7px;width:5px;height:5px;background:var(--navy);border-radius:50%}.signals p{color:var(--muted);font-size:12px}.signals a{font-size:11px;color:var(--green)}.signals>div:not(:first-child){border-color:var(--line)}
.analysis-card{padding-right:26px}.analysis-card .editorial-image{margin-bottom:22px}.analysis-card h3{font-size:29px;line-height:1.13;color:var(--navy)}.analysis-card p{color:var(--muted);font-size:13px}.analysis-card .small{font-size:11px}
th{background:#fff;color:var(--navy);font-size:10px;border-top:1px solid var(--line)}td,th{padding:19px 14px}table{font-size:12px}tbody tr:hover{background:#f9fbfd}.tag,.tag.adc,.tag.bispecific,.tag.equity{color:var(--green);background:var(--tint)}.stats{background:white;border-top:1px solid var(--line);padding:26px 0}.stat strong{color:var(--navy)}.bar{background:#1f4e79}.bar-group:nth-child(even) .bar{background:#5e7c99}.filters input,.filters select,.filters button{background:white}.filters button:hover{background:var(--tint)}.notice{color:var(--muted)}
.page-head h1{color:var(--navy);font-size:50px}.company-card{background:white;border:1px solid var(--line)}.company-card:hover{border-color:#5e7c99}.company-card h2{color:var(--navy)}.company-card .monogram{background:var(--tint);color:var(--navy)}.facts,.aside-box,.related{background:#f9fbfd;border-top:2px solid #1f4e79}.detail-grid>*{min-width:0}.aside-box p{color:var(--muted)}.profile-summary{font-size:15px;line-height:1.85;color:var(--muted)}.status-label{display:inline-block;background:var(--tint);color:var(--green);font-size:10px;padding:6px 9px}.coverage-empty{font-size:13px;color:var(--muted);padding:22px 0}
.article{max-width:900px}.article h1{font-size:56px;line-height:1.08;letter-spacing:-.5px;color:var(--navy)}.article .intro{font-size:25px;line-height:1.5;color:var(--muted)}.article-figure{margin:27px 0 25px}.article-figure .editorial-image{aspect-ratio:16/9}.article-figure figcaption{font:10px/1.7 'DM Sans',Arial,sans-serif;color:var(--muted);margin-top:9px}.article-body{max-width:710px;margin:32px auto}.article-body p{font:18px/1.85 Georgia,serif;color:var(--ink);margin-bottom:25px}.date-line{font:10px/1.8 'DM Sans',Arial,sans-serif;color:var(--muted);margin:12px 0}.evidence-note{font:11px/1.8 'DM Sans',Arial,sans-serif!important;color:var(--muted)!important;border-left:2px solid #5e7c99;padding:10px 16px;background:#f9fbfd}.inline-source{font:10px 'DM Sans',Arial,sans-serif;vertical-align:super;margin-left:5px;color:var(--green);text-decoration:underline;white-space:nowrap}.source-box{border-top:1px solid var(--line);padding-top:20px;margin-top:35px}.source-box h2{font:26px 'Libre Caslon Display',Georgia,serif;color:var(--navy)}.source-box ol{padding-left:20px}.source-box li{padding:8px 0;font:12px/1.7 'DM Sans',Arial,sans-serif;color:var(--muted)}.source-box a{color:var(--green);text-decoration:underline;text-underline-offset:3px;overflow-wrap:anywhere}.source-type{display:block;font-size:10px;color:var(--muted)}.table-note,.article-body .table-note{font:11px/1.8 'DM Sans',Arial,sans-serif;color:var(--muted)}.related{padding:26px}.database-grid{display:grid;grid-template-columns:1fr 1fr;gap:16px}.database-card{border:1px solid var(--line);padding:22px}.database-card h3{font:25px 'Libre Caslon Display',Georgia,serif;margin:0 0 10px}.database-card p{font:13px/1.7 'DM Sans',Arial,sans-serif;color:var(--muted)}
footer{max-width:none!important;margin:0!important;padding:40px max(5%,calc((100% - 1320px)/2)) 28px;background:var(--navy);border:0;color:white}footer .brand{color:white}footer .brand .wordmark{font-size:34px}footer p{color:#dce3ea;font-size:12px;margin-top:20px}footer>div{border-color:#425469;color:#dce3ea}.footer-links{justify-content:flex-start;flex-wrap:wrap;gap:25px}.footer-links span{margin-left:auto}footer a:hover{color:#fff;text-decoration:underline}dialog{background:white}dialog::backdrop{background:#0b1f3aaa}
@media(max-width:1100px){.feature{gap:30px}.feature-copy h1{font-size:44px}.latest-grid .story-row{grid-template-columns:125px minmax(0,1fr)}.latest-grid .story-row h2{font-size:24px}}
@media(max-width:900px){.feature-copy h1{font-size:38px}.feature-copy .deck{font-size:14px}.latest-grid{grid-template-columns:1fr}.latest-grid .story-row{grid-template-columns:200px minmax(0,1fr)}.latest-grid .story-row h2{font-size:29px}.signals{grid-template-columns:1fr 1fr}.article h1{font-size:48px}.story-row{grid-template-columns:180px minmax(0,1fr)}}
@media(max-width:620px){header{gap:16px;padding:23px 0}.brand .wordmark{font-size:35px}.brand .brand-sub{font-size:8px;letter-spacing:3px}.edition{font-size:8px}#nav{gap:18px}nav a{font-size:11px}nav button{min-width:35px;padding:10px 0 10px 8px}.edition-link{font-size:10px}.feature{grid-template-columns:1fr;gap:23px}.feature-copy h1{font-size:39px;line-height:1.07;margin:13px 0}.feature-copy .deck{font-size:15px}.feature-copy .byline{font-size:10px}.feature-image{order:-1}.kicker{gap:20px;align-items:start}.kicker .eyebrow{font-size:9px;max-width:150px}.brief-note{display:block;line-height:1.9;margin-bottom:30px}.brief-note a{display:block;margin-top:8px}.latest-grid .story-row,.story-row{grid-template-columns:1fr;gap:19px;padding:25px 0}.story-row .editorial-image{aspect-ratio:3/2}.latest-grid .story-row h2,.story-row h2{font-size:30px}.story-row p{font-size:14px}.signals{grid-template-columns:1fr;padding:25px 0;gap:22px}.signals>div:not(:first-child){padding:0;border:0}.signals p{font-size:12px}.signals>div:first-child{border-bottom:1px solid var(--line);padding-bottom:12px}.analysis-card{padding:0}.analysis-card h3{font-size:30px}.article h1{font-size:39px;line-height:1.1}.article .intro{font-size:23px}.article-body p{font-size:17px;line-height:1.85}.article-figure .editorial-image{aspect-ratio:3/2}.article-figure{margin-top:23px}.page-head h1{font-size:42px}.database-grid{grid-template-columns:1fr}.footer-links{gap:18px}.footer-links span{margin-left:0;flex-basis:100%}footer{padding-top:35px}.stats{gap:22px}.stat strong{font-size:32px}.section-title{font-size:28px}.small{font-size:11px}}
@media(prefers-reduced-motion:reduce){a{transition:none}}

/* Month hierarchy reuses the existing editorial palette and story rows. */
.archive-month{margin:0 0 30px;border-top:1px solid var(--line)}.archive-month>summary{display:flex;justify-content:space-between;align-items:baseline;gap:20px;cursor:pointer;padding:22px 0;color:var(--navy);font:30px/1.2 "Libre Caslon Display",Georgia,serif}.archive-month>summary .small{font-family:"DM Sans",Arial,sans-serif;font-size:11px}.archive-month>summary:focus-visible{outline:2px solid var(--navy);outline-offset:4px}#nav{min-width:0}nav a{white-space:nowrap}@media(max-width:760px){#nav{overflow-x:auto;scrollbar-width:thin;gap:20px}nav button{flex-shrink:0}.archive-month>summary{flex-wrap:wrap;gap:8px}}